MECHANISMS OF NEURAL-IMMUNE INTERACTIONS UNDER STRESS AND THE APPROACHES TO THEIR CORRECTION
1. Research Institute for Experimental Medicine NWD RAMS, St. Petersburg
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Studies of cytotoxic and proliferative activities of splenocytes as well as concentration of glucocorticoid hormones and testosterone in blood of rats, exposed to cold stress at different regimes, have shown that the changes in functional activity of immune-competent cells depend on the intensity of stress application, whereas alterations in blood hormone level do not depend on these conditions: employment of the both stress models revealed increased corticosterone concentration and reduced testosterone level in rat blood. Novel immunomodulatory effects of native DNA preparation Derinat under stress conditions were shown, including its normalizing action upon changed stress-induced activities of the immune system cells.
Keywords: stress, immune-competent cells, hormones, Derinat